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American Society of Microbiology ABMM Sample Questions (Q45-Q50):

NEW QUESTION # 45
Which pattern on a Kirby-Bauer disk diffusion plate, showing resistance of Staphylococcus aureus to erythromycin but susceptibility to clindamycin with a flattening of the clindamycin zone adjacent to the erythromycin disk (D-zone test positive), indicates inducible clindamycin resistance?

A. Indicates the strain possesses an erm gene and should be reported as clindamycin resistant
B. Indicates the strain should be reported as clindamycin susceptible
C. Indicates the strain possesses the msrA gene
D. Indicates the strain is tolerant to clindamycin

Answer: A

NEW QUESTION # 46
The human virome, the collection of viruses that reside in and on the human body, is increasinglyrecognized for its role in health and disease. Which of the following statements regarding the human virome is MOST accurate?

A. The composition of the human virome is relatively stable over time and is not influenced by environmental factors.
B. The human virome is primarily composed of pathogenic viruses that cause acute infections.
C. Bacteriophages, viruses that infect bacteria, are a significant component of the human gut virome.
D. The human virome is largely independent of the host's immune status.

Answer: C

NEW QUESTION # 47
The gut microbiome has been implicated in the pathogenesis of autoimmune diseases. Dysbiosis, a disruption in the composition and function of the gut microbiota, can lead to increased intestinal permeability and the translocation of microbial products that trigger inflammatory responses. Which of the following bacterial components is a potent activator of the innate immune system and has been linked to the development of autoimmunity?

A. Peptidoglycan
B. Flagellin
C. Lipoteichoic acid (LTA)
D. Lipopolysaccharide (LPS)

Answer: D

NEW QUESTION # 48
A patient with a history of solid organ transplantation develops a severe respiratory illness. Bronchoalveolar lavage fluid is positive for cytomegalovirus (CMV) DNA by PCR, and cytological examination reveals characteristic "owl's eye" inclusions in enlarged cells. The MOST appropriate management strategy for this patient would include:

A. Supportive care and monitoring for spontaneous resolution.
B. Initiation of broad-spectrum antibiotics to cover potential bacterial coinfections.
C. Treatment with antiviral agents such as ganciclovir or valganciclovir.
D. Administration of corticosteroids to reduce inflammation.

Answer: C

NEW QUESTION # 49
A research laboratory is investigating the mechanisms of antigenic variation in Trypanosoma brucei, the causative agent of African trypanosomiasis. The parasite evades the host immune response by periodically changing its surface coat protein. This process primarily involves:

A. RNA interference-mediated silencing of expressed VSG genes followed by activation of a new VSG gene.
B. High-frequency point mutations in the gene encoding the variant surface glycoprotein (VSG).
C. Recombination between different VSG gene loci on minichromosomes.
D. Segmental gene conversion events involving a large repertoire of silent VSG genes.

Answer: D

NEW QUESTION # 50
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